Pyridines and derivatives
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- (1)
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- (1)
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- (6)
- (7)
- (12)
- (1)
- (1)
- (39)
- (1)
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- (11)
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- (1)
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- (1)
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- (1)
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- (1)
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Filtered Search Results
Medchemexpress LLC Dac590 | 3084407-00-8 | 96.15% | 390.79 | 5 MG
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Dac590 is an orally active FTO inhibitor. It exhibits a robust antiproliferative effect on AML cells, inducing apoptosis and cell cycle G1 arrest by inhibiting oncogenic FTO signaling. Dac590 significantly inhibits tumor growth and prolongs survival without observed toxicity in acute myeloid leukemia (AML) xenograft mice models, and shows a synergistic effect when combined with Decitabine.
- Orally active FTO inhibitor
- Robust antiproliferative effect on AML cells
- Induces apoptosis and cell cycle G1 arrest
- Inhibits oncogenic FTO signaling
- Significantly inhibits tumor growth
- Prolongs survival in AML xenograft models
- Shows synergistic effect with Decitabine
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000386555 ADRENOSTERONE STAND 100MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000386843 CHLOROQUINE STANDAR 5MG
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Medchemexpress LLC Fidaxomicin | 873857-62-6 | 99.8% | 1058.04 | 50 MG
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Fidaxomicin is a macrocyclic antibiotic that acts as an orally active and potent RNA polymerase inhibitor. It exhibits a narrow spectrum of antibacterial activity and is particularly effective against *Clostridium difficile* (MIC90=0.12 μg/mL), making it suitable for research related to *Clostridium difficile* infection (CDI).
- Selectively eradicates pathogenic *Clostridium difficile* with minimal disruption to normal, healthy intestinal flora.
- Minimally impacts commensals and does not inhibit commonly cultured bowel commensals (MIC90 >1024 μg/mL).
- Completely prevents lethality and relapses in a hamster model for pseudomembranous colitis.
- Prevents development of antibiotic-induced *C. difficile* colitis in hamsters at doses as low as 0.2 mg/kg.
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Medchemexpress LLC Quercetin | 117-39-5 | 99.8% | 302.24 | 1 ML
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Quercetin is a natural flavonoid that acts as a stimulator of recombinant SIRT1 and an inhibitor of PI3K, with IC50 values of 2.4 μM for PI3K γ, 3.0 μM for PI3K δ, and 5.4 μM for PI3K β. This product is intended for research use only.
- Natural flavonoid
- Stimulator of recombinant SIRT1
- PI3K inhibitor with IC50 values for PI3K γ, PI3K δ, and PI3K β
- Appears in 194 publication(s) in Google Scholar
- Available in solid and solution forms
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Medchemexpress LLC Mizoribine (Standard) | 50924-49-7 | 99.9% | 259.22 | 5 MG
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Mizoribine (Standard) is the analytical standard of Mizoribine, intended for research and analytical applications. This imidazole nucleoside inhibits HCV RNA replication with an IC50 of approximately 100 μM for anti-HCV activity. It acts as an immunosuppressant and an IMPDH inhibitor, also inhibiting the replication of SARS-CoV with IC50s of 3.5 μg/mL for SARS-CoV Frankfurt-1 and 16 μg/mL for SARS-CoV HKU39849.
- Analytical standard for research and analytical applications
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
- Inhibits HCV RNA replication with an IC50 of approximately 100 μM
- Acts as an immunosuppressant
- Inhibits replication of SARS-CoV with IC50s of 3.5 μg/mL and 16 μg/mL
- Solid, white to off-white appearance
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Medchemexpress LLC Sacubitril/Valsartan | 936623-90-4 | 100.0% | 957.99 | 500 MG
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Sacubitril/Valsartan (LCZ696) is comprised of Valsartan and Sacubitril (AHU377) in a 1:1 molar ratio. It is a first-in-class, orally bioavailable, and dual-acting angiotensin receptor-neprilysin (ARN) inhibitor. It is used for hypertension and heart failure and ameliorates diabetic cardiomyopathy by inhibiting inflammation, oxidative stress, and apoptosis.
- First-in-class and orally bioavailable.
- Dual-acting angiotensin receptor-neprilysin (ARN) inhibitor.
- Ameliorates diabetic cardiomyopathy by inhibiting inflammation, oxidative stress, and apoptosis.
- Exhibits small weights and reduces interstitial fibrosis in cardiac remodeling and dysfunction after myocardial infarction.
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Medchemexpress LLC Chloroquine (standard) | 54-05-7 | 99.5% | 319.87 | 2 G
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Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. It functions as an autophagy and toll-like receptors (TLRs) inhibitor, and it has demonstrated high effectiveness in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM).
- Inhibits IL-12p70 release and reduces Th1-priming capacity.
- Enhances IL-1-induced IL-23 secretion.
- Suppresses MMP-9 mRNA expression.
- Reduces HuH7 cell proliferation through TLR7 and TLR9 inhibition.
- Potently blocks SARS-CoV-2 virus infection.
- Blocks virus infection by increasing endosomal pH and interfering with receptor glycosylation.
- Inhibits tumor growth in xenograft models.
- Inhibits HCC development in rat models.
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Medchemexpress LLC PYRIMETHAMINE 10MM | 10MM/1ML
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PYRIMETHAMINE 10MM | 10MM/1ML
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Medchemexpress LLC Amentoflavone | 1617-53-4 | 538.46 | 10 MM 1 ML
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Amentoflavone is a potent and orally active GABA(A) negative modulator. It exhibits a wide range of biological activities including anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, and antibacterial effects. It also induces apoptosis and cell cycle arrest at the sub-G1 phase.
- Potent and orally active GABA(A) negative modulator
- Exhibits anti-inflammatory activity
- Exhibits antioxidative activity
- Exhibits anti-viral activity
- Exhibits anti-tumor activity
- Exhibits anti-radiation activity
- Exhibits anti-fungal activity
- Exhibits antibacterial activity
- Induces apoptosis
- Induces cell cycle arrest at the sub-G1 phase
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Medchemexpress LLC Vitexin-2''-O-rhamnoside | 64820-99-1 | 578.52 | 1 ML
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Vitexin-2"-O-rhamnoside is an orally active flavonoid glycoside that plays a role in various biological processes. It inhibits apoptosis, increases phosphorylation levels of PI3K/Akt, and inhibits caspase-3 and SOD activity. The compound also promotes the secretion of cytokines such as IL-2, IL-6, and IL-12. It strongly inhibits DNA synthesis in MCF-7 cells with an IC50 of 17.5 μM. This product is used in the study of cardiovascular disease and immune-related diseases.
- Enhances immune function
- Improves absorption of active compounds
- Exhibits antioxidant activity
- Utilized in research for cardiovascular and immune-related conditions
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Medchemexpress LLC YM-1 | 409086-68-6 | 98.49% | 417.98 | 100 MG
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YM-1 is a stable MKT-077 analog and an orally active Hsp70 inhibitor. It induces cell death in HeLa cells and up-regulates the levels of p53 and p21 proteins. For research use only, not for sale to patients.
- Stable MKT-077 analog
- Orally active Hsp70 inhibitor
- Induces cell death of HeLa cells
- Up-regulates p53 and p21 proteins
- Promotes Hsp70-dependent steps in nNOS maturation
- Partially blocks formation of the ATP-bound form of Hsp70
- Activates binding of Hsp70 to its unfolded substrate
- Converts Hsp70 to its tight-affinity conformation with an IC50 of 8.2 μM
- Promotes nNOS ubiquitination
- Weakens dihydrotestosterone (DHT)-dependent eye degeneration phenotype and rescues DHT-dependent pupal toxicity of polyQ AR in Drosophila
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Medchemexpress LLC Vitexin-2"-O-rhamnoside | 64820-99-1 | 578.52 | 1 MG
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Vitexin-2"-O-rhamnoside is an orally active flavonoid glycoside. It inhibits apoptosis and promotes cytokine secretion, demonstrating significant activity against DNA synthesis in MCF-7 cells. This compound enhances immune function, improves the absorption of active compounds, and exhibits antioxidant properties, making it valuable for cardiovascular and immune-related research.
- Orally active flavonoid glycoside
- Inhibits apoptosis and caspase-3 activity
- Increases PI3K/Akt phosphorylation levels
- Promotes cytokine (IL-2, IL-6, IL-12) secretion
- Strongly inhibits DNA synthesis in MCF-7 cells (IC50 of 17.5 μM)
- Enhances immune function and improves absorption of active compounds
- Possesses antioxidant activity
- Useful in cardiovascular and immune-related disease studies
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Medchemexpress LLC Stevioside | 57817-89-7 | 804.87 | 50 MG
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Stevioside is an orally active sweetener that can be isolated from Stevia rebaudiana. It exhibits several beneficial activities, including antihypertensive, antihyperglycemic, antioxidant, anti-inflammatory, and anti-tumor properties.
- Antihypertensive activity
- Antihyperglycemic activity
- Antioxidant activity
- Anti-inflammatory activity
- Anti-tumor activities
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Medchemexpress LLC Ciraparantag | 1438492-26-2 | 98.0% | 512.70 | 100 MG
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Ciraparantag is a thrombin and factor Xa inhibitor that acts as a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It has been reported to antagonize the effects of all coagulants except VKAs and agratroban.
- Thrombin and factor Xa inhibitor.
- Broad-spectrum reversal agent for anticoagulants.
- Reverses the effects of low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants.
- A small synthetic and cationic molecule that binds direct Xa inhibitors, direct thrombin inhibitors, and unfractionated and low molecular weight heparin (LMWH) through non-covalent hydrogen bonds and charge-charge interactions.
- Demonstrates reversal of anticoagulants with thromboelastography studies and reduced bleeding in rat-tail transection bleeding assays.
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